From MSNBC:

WASHINGTON - U.S. researchers said on Monday they had identified a genetic mutation that raises the risk of autism and could also explain some of the other symptoms seen in children with autism.

Although autism and similar disorders can clearly run in families, theirs is the first study to find a definitive genetic link to the disorder, which affects as many as 1 in 175 U.S. children.

Dr. Pat Levitt and colleagues at Vanderbilt University in Nashville, Tenn., studied 743 families in which 1,200 family members were affected by autism spectrum disorders, which range from fully disabling autism to Asperger’s syndrome.

They found a single mutation in a gene called MET, which is known to be involved in brain development, regulation of the immune system and repair of the gastrointestinal system. All of these systems can be affected in children with autism.

“This is a vulnerability gene,” Levitt said. “There are not genes that actually cause autism. It raises the risk.”

2 copies of gene double the risk
People with two copies of the mutated gene have 2 to 2.5 times the normal risk of autism and people with one mutated copy have 1.7 times the risk, he said.

The findings, published in the Proceedings of the National Academy of Sciences, offer a way to start looking for the actual causes of autism, Levitt said.

Autism can cause a range of symptoms, from fairly mild social dysfunction to severe and disabling learning and social impairments.

Researchers knew it could run in families, but the cause has been unknown. Children are usually diagnosed as toddlers, with parents often describing a sudden regression in abilities and behavior. There is no known cure.

Levitt said the mutation does not change the function of the gene, but changes gene expression — how active the gene is.

Levitt says his team will now try to make a rat or a mouse with the same genetic mutation and use it to study what in the environment might cause autism in people with the mutation.

“It may be more than one thing,” Levitt said.

“Let’s say it is exposure to some chemical. It is a long list of everything from food additives to mercury to fertilizers. This will help.”

Questions on vaccines
Levitt said his study may help answer questions about links between vaccines and autism.

Experts virtually all agree that vaccines do not cause autism but some parents remain mistrustful. The U.S. Centers for Disease Control and Prevention has launched a series of studies into the potential causes of autism.

In a second study, a team at Cornell University and Indiana University-Purdue University found that television viewing may be a factor among American children.

Michael Waldman of Cornell University and colleagues found that children from rainy U.S. counties watch more television and autism rates corresponded with this pattern.

“The analysis shows that early childhood television viewing could be an environmental trigger for the onset of autism and strongly points to the need for more research by experts in the field of autism,” said Waldman, who will present his findings on Friday to a conference of the National Bureau of Economic Research.

A third team of researchers found that the brain regions of adults with autism may not communicate with each other as efficiently as they do in other people.

Michael Murias and colleagues at the University of Washington used high-resolution electroencephalography or EEG to find patterns of abnormal connectivity between brain regions in 36 people with autism.

Copyright 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters.

That is very interesting. We are getting a genetic study done on our ds in January at the suggestion of the psychologist who dx'd ds w/ADD (some feel that it is an autistic spectrum disorder) this past summer. I'll be keeping my eye on this new information. It feels so good to see some progress being made in terms of autism reasearch. Every little bit helps.

On a side note, I'm wondering if anyone here with an ASD child has anyone else in their family on the spectrum. I have always heard it does run in families but we don't have anyone else in our family w/an ASD and if they did they are so high functioning that one would not notice.

This will definately open up many doors for research, hopefully in a few years there will be more answers than questions.

Goodnightmoon: I believe my family is an example of where ASD can run in families. In studying Aspergers for my 6 year old son, I read examples of how he sees the world and I'm like, and so?...I can totally relate. I then took a few self-tests before mentioning it to the therapist, and I, too, may have Aspergers. I think my dh does, to some degree, and I'm positive his brother does. I have two brothers, one I'm not sure exactly what all he has, but he definitely always had OCD and many other issues. Another brother did not speak until he was four, never crawled, walked when he was three, and had MANY issues, turning into schizophrenia in later years. Unfortunately, we were all products of abuse, so I've seen the harm harshness can cause in children like this. (ASD children, and especially Aspergers, are susceptible to mental issues, such as depression, schizo, etc.). My sister rocked herself, hurting her tummy by scratching as she cried as a child. I know there are other factors, but I definitely feel one, if not two, of my brothers is definitely autistic. However, they are 2500 miles away and I very rarely see them.

I don't think having a family member with ASD means everyone will have it. Rather, the risk level is higher. There's something there that makes that switch flip, and this research is supporting that theory.

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